Levothyroxine Sodium 50mcg is used to treat an underactive thyroid gland (hypothyroidism). It helps regulate energy and metabolism by replacing the hormone that the thyroid gland fails to produce in adequate amounts.
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Levothyroxine (Thyroid Hormones)
Mechanism of Action:
Take on an empty stomach with a full glass of water, 30 minutes to 1 hour before meals.
Consumption of alcohol is not recommended during management with Thyrox 50mcg Tablet.
Thyrox 50mcg Tablet is not recommended for use in pregnant women unless necessary. Consult your doctor for advice.
Thyrox 50mcg Tablet is not recommended for use in breastfeeding women unless necessary. Consult your doctor for advice.
Thyrox 50mcg Tablet does not usually affect your ability to drive.
Thyrox 50mcg Tablet should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
Thyrox 50mcg Tablet should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Thyrox 50 contains synthetic levothyroxine, which is identical to the natural thyroid hormone T4. In the body, T4 is converted to the more active triiodothyronine (T3). Levothyroxine helps normalize thyroid hormone levels, thus regulating metabolism, energy production, and various bodily functions.
Mild Hypothyroidism:
- 1.7 mcg/kg or 100-125 mcg daily; maximum 300 mcg/day.
For individuals over 50 years old (or under 50 with cardiovascular disease):
- Initial dose: 25-50 mcg/day.
- Adjust the dose by 12.5-25 mcg every 6-8 weeks.
For individuals over 50 years with cardiovascular disease:
- Initial dose: 12.5-25 mcg/day.
- Adjust the dose by 12.5-25 mcg every 4-6 weeks until the patient reaches euthyroid status and serum TSH levels normalize.
Severe Hypothyroidism:
- Initial dose: 12.5-25 mcg/day.
- Adjust by 25 mcg every 2-4 weeks as needed.
Subclinical Hypothyroidism:
- Initial dose: 1 mcg/kg daily may be sufficient, or if replacement therapy is not started, monitor the patient's clinical status and TSH levels annually.
TSH Suppression:
- For thyrotropin-dependent well-differentiated thyroid cancer: doses over 2 mcg/kg/day may be administered to suppress TSH to less than 0.1 MIU/L.
- For benign nodules and nontoxic multinodular goitre: target TSH levels are 0.1-0.5 MIU/L for nodules and 0.5-1 MIU/L for multinodular goitre.
Hypothyroidism:
Age 1-3 months:
- 10-15 mcg/kg/day.
- For patients at risk of cardiac failure, start with a lower dose (25 mcg/day).
- If initial serum T4 is lower than 5 mcg/dL, start treatment at a higher dose (50 mcg/day).
Age 3-6 months:
- 8-10 mcg/kg/day or 25-50 mcg/day.
Age 6-12 months:
- 6-8 mcg/kg/day or 50-75 mcg/day.
Age 1-5 years:
- 5-6 mcg/kg/day or 75-100 mcg/day.
Age 6-12 years:
- 4-5 mcg/kg/day or 100-125 mcg/day.
Over 12 years:
- 2-3 mcg/kg/day or 150 mcg/day.
For children with severe or chronic hypothyroidism:
- Start with 25 mcg/day and adjust the dose by 25 mcg weekly.
Hypersensitivity
The need for Levothyroxine may increase during pregnancy. Although thyroid hormones are excreted in small amounts in breast milk, appropriate replacement doses are generally required to maintain normal lactation. Always consult your doctor for advice specific to your situation.
Store Thyrox 50 in a cool, dry place protected from light. Keep it out of the reach of children.
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